The power of network-based drug design and the interplay between metabolism and gene expression in Trypanosoma brucei
نویسنده
چکیده
The power of network-based drug design and the interplay between metabolism and gene expression in Trypanosoma brucei
منابع مشابه
Efficacy of repeated doses of diminazene aceturate (Dinazene®) in the treatment of experimental Trypanosoma brucei infection of Albino rats
The efficacy of repeated doses of Dinazene® in Albino rats experimentally infected with Trypanosoma brucei (Gboko strain) was investigated. A total of 30 adult female Albino rats weighing 130-190 g were used for the study. They were assigned to six groups (groups A-F) of five rats each. Groups A-D were infected intraperitoneally with 1.0 × 106 trypanosomes in 400 μL of PBS diluted blood while g...
متن کاملNetwork-based transcriptome analysis in salt tolerant and salt sensitive maize (Zea mays L.) genotypes
Identification of genes involved in salinity stress tolerance provides deeper insight into molecular mechanisms underlying salinity tolerance in maize. The present study was conducted in the faculty of agriculture of Urmia university, Iran, in 2018, with the aim of identifying genetic differences between two maize genotypes in tolerance to salinity stress, and the results of gene expression wer...
متن کاملInvestigation on metabolism of cisplatin resistant ovarian cancer using a genome scale metabolic model and microarray data
Objective(s): Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. Material and Methods:Metabolism of c...
متن کاملThe cell biology of parasitism in Trypanosoma brucei: insights and drug targets from genomic approaches?
The African trypanosome, Trypanosoma brucei exhibits a complex, digenetic life cycle that alternates between the tsetse fly vector and the mammalian host. The life cycle is characterised by a complex series of cell type differentiations and variations in metabolism. In addition the trypanosome exhibits a particular cell biology that has become adapted for its role as a parasite. This article pl...
متن کاملFlux Analysis of the Trypanosoma brucei Glycolysis Based on a Multiobjective-Criteria Bioinformatic Approach
Trypanosoma brucei is a protozoan parasite of major of interest in discovering new genes for drug targets. This parasite alternates its life cycle between the mammal host(s) (bloodstream form) and the insect vector (procyclic form), with two divergent glucose metabolism amenable to in vitro culture. While the metabolic network of the bloodstream forms has been well characterized, the flux distr...
متن کامل